Table 1.

EGFR mutational analysis by Sanger sequencing and NGS of cytological samples with and without morphologic evidence of neoplastic cells

Cytological samples EGFR +ve
EGFR mutational analysisSurgical samples EGFR +veSanger (%)NGS (%)
With morphologic evidence of neoplastic cells
 Deletion exon 19224 (18%)19 (86%)
 Point Mutation exon 21141 (7%)10 (71%)
 Total number365 (14%)29 (81%)
Without morphologic evidence of neoplastic cells
 Deletion exon 19703 (43%)
 Point Mutation exon 21502 (40%)
 Total number1205 (42%)

Abbreviations: +ve = positive; NGS = next generation sequencing.