Table 6.

Summary of current data supporting CYP17A1 SNPs as germline prognostic molecular markers of prostate cancer progression

Wright and colleagues (32)Hamada and colleagues (31)Yamada and colleagues (30)This study
Sample size (n)598222214526601
Ethnic backgroundCaucasianCaucasianAsian JapaneseCaucasianAsian Taiwanese
Disease stage TreatmentLocalized (RP/radiation/ADT)Advanced (CRPC)Advanced (ADT)Localized (RP)Advanced (ADT)
CYP17A1
 rs6162(G)
 rs743572 (A)a
 rs10883783 (T)n/sn/sn/s

NOTE: Bold, significant P values.

Abbreviations: RP, radical prostatectomy; n/s, nonsignificant; ─, not evaluated.