Table 1.

Association between GPER1 intensity score and various clinicopathologic variables in cohorts I and II

Cohort ICohort II
GPER1 intensityGPER1 intensity
FactorPatient01234PaPatient01234Pa
NN (%)NN(%)
All27324 (9)38 (14)125 (46)75 (27)11 (4)20820 (10)69 (33)87 (42)23 (11)9 (4)
Age, years0.180.003
Node status
 Negative898 (9)16 (18)30 (34)26 (29)9 (10)0.26
 Positive18316 (9)22 (12)94 (51)49 (27)2 (1)
 Missing1
Tumor size
 ≤20 mm805 (6)12 (15)42 (53)21 (26)0 (0)0.5615510 (6)51 (33)69 (45)18 (12)7 (5)0.05
 >20 mm19319 (10)26 (13)83 (43)54 (28)11 (6)5310 (19)18 (34)18 (34)5 (9)2 (4)
Histologic grade
 1150 (0)1 (7)6 (40)8 (53)0 (0)0.88620 (0)16 (26)34 (55)10 (16)2 (3)0.0003
 217619 (11)18 (10)89 (51)45 (26)5 (3)775 (6)25 (32)39 (51)6 (8)2 (3)
 3733 (4)17 (23)27 (37)20 (27)6 (8)6715 (22)28 (42)13 (19)6 (9)5 (7)
 Missing92
ER
 Positive20615 (7)20 (10)99 (48)67 (33)5 (2)0.011387 (5)36 (26)73 (53)17 (12)5 (4)0.0005
 Negative668 (12)18 (27)26 (39)8 (12)6 (9)7013 (19)33 (47)14 (20)6 (9)4 (6)
 Missing1
PgR
 Positive16411 (7)16 (10)76 (46)57 (35)4 (2)0.0115110 (7)39 (26)79 (52)19 (13)4 (3)0.0004
 Negative10812 (11)22 (20)49 (45)18 (17)7 (6)5710 (18)30 (53)8 (14)4 (7)5 (9)
 Missing1
HER2
 Negative20616 (8)30 (15)92 (45)57 (28)11 (5)0.7617317 (10)52 (30)77 (45)19 (11)8 (5)0.45
 Positive342 (6)4 (12)19 (56)9 (26)0 (0)221 (5)11 (50)7 (32)3 (14)0 (0)
 Missing4313
Ki67
 Low (≤20%)17013 (8)20 (12)80 (47)51 (30)6 (4)0.241277 (6)31 (24)69 (54)16 (13)4 (3)0.0007
 High (>20%)979 (9)17 (18)44 (45)23 (24)4 (4)609 (15)32 (53)11 (18)5 (8)3 (5)
 Missing621
  • aTest for zero slope in a linear regression, which equals a χ2 test for trend for binary variables.