Table 3.

DDFS by Cox univariate and multivariate analysis in the ER-positive subgroup of cohort II

Univariate DDFSMultivariate DDFS
VariableNHR (95% CI)PNHR (95% CI)Pb
Age (linear, y)1380.90 (0.84–0.96)0.0021200.88 (0.82–0.95)0.001
GPER1 (trend)1380.62 (0.39–0.99)0.051200.60 (0.34–1.1)0.09
Tumor size (>20 mm vs. ≤20 mm)1381.1 (0.44–2.7)0.851200.78 (0.30–2.0)0.60
Histologic grade1360.02a1200.59a
 1 vs. 30.28 (0.11–0.73)0.010.65 (0.17–2.6)0.54
 2 vs. 30.34 (0.14–0.82)0.020.53 (0.16–1.8)0.31
HER2 (pos vs. neg)1322.4 (0.85–7.1)0.141200.77 (0.23–2.5)0.66
PgR (pos vs. neg)1380.88 (0.21–3.7)0.871204.5 (0.81–25.1)0.09
Ki67 (>20% vs. ≤20%)1243.9 (1.8–8.6)0.0021203.3 (1.0–10.6)0.05
  • aP value for histologic grade as a factor on 3 levels.

  • bFor some factors, the much higher P values in multivariate analysis, compared with univariate analysis, can be explained by a high degree of colinearity between the variables in the model.