Table 2.

Joint frequency distribution of mutations across all gene pairs in patient tumor specimens available for analysis (N = 288)

Gene, nAKT1, n = 1BRAF, n = 18CTNNB1, n = 5EGFR, n = 3KRAS, n = 124NRAS, n = 14PIK3CA, n = 24PTEN, n = 15TP53, n = 167
AKT1
BRAF1
CTNNB1
EGFR
KRASa213
NRAS3
PIK3CA2113
PTEN41611
TP53811669129

NOTE: AKT1, v-akt murine thymoma viral oncogene homolog 1; BRAF, v-raf murine sarcoma viral oncogene homolog B1; CTNNB1, catenin (cadherin-associated protein), β-1, 88 kDa; KRAS, v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog; NRAS, neuroblastoma RAS viral oncogene homolog; PIK3CA, phosphoinositide-3-kinase, catalytic, α-polypeptide; PTEN, phosphatase and tensin homolog; TP53, tumor protein p53.

  • aKRAS mutations in codons 12, 13, or 61.