Table 2.

DDFS by Cox univariate and multivariate analysis in the ER-positive subgroup of cohort I

Univariate DDFSMultivariate DDFS
VariableNHR (95% CI)PNHR (95% CI)P
Age (linear, y)2060.99 (0.97–1.02)0.621991.00 (0.97–1.03)0.93
GPER1 (trend)2060.66 (0.49–0.88)0.0071990.67 (0.50–0.92)0.01
Node status (N+ vs. N0)2061.23 (0.66–2.28)0.521991.60 (0.83–3.07)0.16
Tumor size (>20 mm vs. ≤20 mm)2061.95 (0.95–4.02)0.051992.22 (1.04–4.72)0.04
Histologic grade2020.18a1990.46a
 1 vs. 30.22 (0.03–1.76)0.160.45 (0.05–3.80)0.46
 2 vs. 30.93 (0.45–1.93)0.851.24 (0.55–2.81)0.60
HER2 (pos vs. neg)1810.96 (0.38–2.46)0.93b
PgR (pos vs. neg)2060.84 (0.45–1.59)0.601990.99 (0.51–1.94)0.98
Ki67 (>20% vs. ≤20%)2032.02 (1.15–3.56)0.021992.01 (1.05–3.88)0.04
  • aP value for histologic grade as a factor on 3 levels.

  • bHER2 excluded because of a higher frequency of missing data than the other variables.