Table 3.

Per-course responses to treatment

First-line, n (%)Second-line, n (%)
Course 1Course 2Course 1Course 2
RECIST
All evaluable84695033
CR1 (1)1 (1)00
PD4 (5)4 (6)5 (10)6 (18)
PR19 (23)23 (33)13 (26)10 (30)
SD60 (71)41 (59)32 (64)17 (52)
Bone
All evaluable85714925
CR0000
PD7 (8)3 (4)10 (20)5 (20)
PR0000
SD78 (92)68 (96)39 (80)20 (80)
PSA
All evaluable67544319
CR02 (4)2 (5)1 (5)
PD7 (10)8 (15)18 (42)6 (32)
PR19 (28)23 (43)5 (12)5 (26)
SD41 (61)21 (39)18 (42)7 (37)
CEA
All evaluable26202014
CR0000
PD3 (12)4 (20)2 (10)3 (21)
PR1 (4)5 (25)4 (20)5 (36)
SD22 (85)11 (55)14 (70)6 (43)
Overall
All evaluable113937441
PD19 (17)19 (20)31 (42)17 (41)
No PD94 (83)74 (80)43 (58)24 (59)

Abbreviations: RECIST, response evaluation criteria in solid tumors; CR, complete response; SD, stable disease; PSA, prostate-specific antigen; CEA, carcinoembryonic antigen.