Table 5.

Summary of Kaplan–Meier survival analysis (overall and subgroup—radical and palliative treatment) for each prognostic factor in the validation dataset (using the threshold from the feasibility dataset)

Overall—mean survival in months (patients, n)Radical—mean survival in months (patients, n)Palliative—mean survival in months (patients, n)
Tumor characteristicsThreshold (cutoff)Above thresholdBelow thresholdOverall P (Kaplan–Meier)Above thresholdBelow thresholdRadical P (Kaplan–Meier)Above thresholdBelow thresholdPalliative P (Kaplan–Meier)
Heterogeneity (CTTA–normalized entropy, medium/coarse scale)<1.233a39.7 (19)18.2 (47)<0.00141.2 (12)24.5 (20)0.02732.0 (6)14.0 (26)0.042
Heterogeneity (PTA–entropy without filtration)>3.20916.3 (33)31.8 (33)0.00320.0 (10)34.3 (22)0.15714.2 (23)23.4 (9)0.313
Clinical stage>IIa10.8 (26)33.1 (40)<0.00111.6 (5)35.0 (27)0.07010.2 (20)25.6 (12)0.020
SUVmax>22.8a11.5 (9)25.9 (57)0.94811.0 (3)33.0 (29)0.72711.4 (6)16.3 (26)0.321
Permeability<14.33130.0 (43)14.4 (23)0.00234.5 (23)25.0 (9)0.17922.4 (20)4.7 (12)0.003
Treatment (radical = 0; palliative = 1)>017.1 (32)32.4 (34)0.002
  • aOptimal threshold derived from the feasibility dataset.