Table 2.

Somatic BRAF mutations identified

ExonNucleotide changeAmino acid changeFrequency, N
111391G>AG464Ea1
1391G>TG464Vb1
1396G>AG466R1
1397G>TG466Vc4
1406G>CG469A2
1405_1407delGGAG469del1
1406G>TG469V1
151780G>AD594N1
1781A>GD594G2
1801A>GK601E1
1794_1796dupTACT599_V600insT1
1799_1801delTGAV600_K601delinsE1
1799T>AV600Ed18
1798G>TV600L1

Abbreviations: del, deletion; dup, duplication; ins, insertion.

  • aOne patient had both BRAF G464E and KRAS G12A.

  • bOne patient had both BRAF G464V and KRAS G13C.

  • cOne patient had both BRAF G466V and KRAS G12C.

  • dOne patient had both BRAF V600E and PIK3CA E545K.