Table 1.

pCR rates across different patient subsets for the RESP-HUM and UNTREATED-HUM signatures

RESP-HUMUNTREATED-HUM
pCRResidual diseasePAUCORPAUCOR
All patients91 (19.7%)371 (80.3%)0.0510.5860.788 (0.61–0.99)<0.0010.7522.72 (2.08–3.63)
ER negative only62 (33.3%)124 (66.7%)0.821<0.0010.6832.09 (1.44–3.11)
ER positive only29 (10.5%)246 (89.5%)0.405<0.0010.7472.64 (1.67–4.31)
PAM50 (5 intrinsic subtypes)
Basal-like62 (35.8%)111 (64.2%)0.7070.0010.6492.05 (1.33–3.24)
HER2-enriched5 (17.9%)23 (82.1%)0.4300.076
Luminal A4 (2.8%)141 (97.2%)0.2080.172
Luminal B12 (16.7%)60 (83.3%)0.6380.079
Normal-like8 (18.2%)36 (81.8%)0.0090.8374.47 (1.69–16.9)0.274
PAM50 + Claudin-low (6 intrinsic subtypes)
Basal-like51 (39.5%)78 (60.5%)0.3560.0010.6802.33 (1.44–3.93)
Claudin-low16 (22.9%)54 (77.1%)0.0540.6601.55 (1–2.47)0.474
HER2-enriched5 (18.5%)22 (81.5%)0.4260.086
Luminal A4 (2.9%)136 (97.1%)0.2230.169
Luminal B11 (16.2%)57 (83.8%)0.9760.272
Normal-like4 (14.3%)24 (85.7%)0.0520.137
Triple negative only56 (33.5%)111 (66.5%)0.6510.0030.6511.8 (1.24–2.68)

NOTE: The P value and AUC columns indicate whether the RESP-HUM or UNTREATED-HUM signature (as a continuous variable from low to high expression) was associated with response (italics) within that patient set/subset.