Table 1.

Summary of pharmacokinetic parameters for onartuzumab in mice and cynomolgus monkeys with noncompartmental analysis

SpeciesDose (mg/kg)Cmax (μg/mL)AUCinf (d*μg/mL)CL (mL/d/kg)Vss (mL/kg)t1/2 (d)
Athymic nude mouse (n = 3/time point)359.916218.61465.95
1020351419.41567.22
306691,18025.41315.13
Cynomolgus monkey (n = 4)0.511.7 ± 1.5913.1 ± 3.1534.8 ± 8.5981.2 ± 17.42.53 ± 0.278
391.8 ± 3.08190 ± 27.315.3 ± 2.6255.6 ± 3.792.39 ± 0.300
10300 ± 86.5786 ± 88.811.9 ± 1.3164.5 ± 5.503.21 ± 0.489
30876 ± 1072,330 ± 13112.4 ± 0.65973.8 ± 7.693.53 ± 0.819