Table 2.

Copy number variations assessed by DNA array (n = 29)

Chromosome armType of CNVCases (n/%; 95% CI)ROI Start bpROI End bpSize (Mb)
1pLoss13 (45%; 95% CI, 28–63%)56572171685150211.2
3pLoss4 (19%; 95% CI, 6–31%)47478496501562512.7
13qLoss5 (17%; 95% CI, 8–35%)45307552497985044.5b
14qLossa17 (59%; 95% CI, 41–75%)26370859286521352.3
41327139464361895.1
5414219010689737952.8
15qLoss7 (24%; 95% CI, 12–42%)49340635561429026.8
22qLoss11 (38%; 95% CI, 23–56%)287728165113418622.4
1qGain3 (10%; 95% CI, 5–33%)118649839249224376232.4
4qGain6 (21%; 95% CI, 10–38%)52920476561804783.3c
5qGain8 (28%; 95% CI, 15–46%)12064575518064510160.0
7pGain3 (10%; 95% CI, 5–33%)70584236270640455.7
11qGain4 (19%; 95% CI, 6–31%)7884612513494477056.1
12pGain3 (10%; 95% CI, 5–33%)4790741563579615.2

ROI (region of interest) denotes minimal region of overlap, genome annotations applied in data analysis refer to the human reference assembly GRCh37/hg19.

  • aThe minimal region of overlap on chromosome 14 comprised 3 regions with a total size of 60.2 Mb.

  • bRB1 is located within the minimal region of overlap.

  • cKIT and PDGFRA are located within the minimal region of overlap, respectively.