Table 4.

Expression of proteins and correlation of overexpression with prognostic parameters

ProteinNumber of investigated casesPrimary staining patternPositive cases95% CIFletcher riskMiettinen riskUICC stagingUICC mitotic rateLocalizationSurvivalKIT mutations
RBM5118Nucleus108 (91.5%)85.1–95.3%
RAD54L2114Nucleus11 (9.6%)5.5–16.5%YesYesShorter OS
RB1106Nucleus20 (18.9%)12.6–27.4%
SYNE2128Nucleus23 (18%)12.3–25.5%YesYesYesSmall intestinalShorter DFS
USP8120Cytoplasm108 (90%)83.3–94.2%
AP1B174Cytoplasm74 (100%)95.1–100%
GTSE1119Cytoplasm14 (11.8%)7.1–18.8%Small intestinal
MAPK8IP2137Cytoplasm69 (50.4%)42.1–58.6%
KIT145Cytoplasm126 (86.9%)80.4–91.5%Yes (neg.)Yes (neg.)Longer OSYes
DIAPH1119Cytoplasm54 (45.4%)36.7–54.3%YesYesYesYesShorter DFS
FLT475Cytoplasm30 (40%)29.7–51.3%

Abbreviation: neg., negative correlation.