Table 1.

Correlation between expression of p-AMPK (Thr172) and clinicopathological characteristics in 273 HCCs

High p-AMPKLow p-AMPK
(Thr172; n = 76)(Thr172; n = 197)Pa
Age
 <50431090.892
 ≥503388
Gender
 Male671650.451
 Female932
HBV Infection
 Yes691840.446
 No713
AFP (ng/mL)
 ≥200241090.000448
 <2005288
Liver cirrhosis
 Yes561470.878
 No2050
Maximal tumor size (cm)
 <524670.775
 ≥552130
Tumor multiplicity
 Single661530.0932
 Multiple1044
Tumor encapsulation
 Incomplete351310.00235
 Complete4166
Edmondson grade
 I/II23280.00324
 III/IV53169
Pathologic TNM stage
 Early stage (I-II)56950.00014
 Late stage (III)20102
Portal vein thrombosis
 Absence701500.00207
 Gross647
Distant metastasis
 Absent731630.00281
 Present334
Child-Pugh stageb
 A721830.78677
 B414
MELDc Score
 <10711880.99999
 ≥1039
  • aFisher exact test.

  • bNo patients with Child-Pugh C were included.

  • cMELD (the model for end-stage liver disease). Significant results (P < 0.05) are given in bold.