Table 3.

Bicalutamide-related adverse events per NCI CTCAE version 3

ToxicityGrade 1 (n)Grade 2 (n)Grade 3 (n)
AST511
ALT51
Hyperbilirubinemia1
Alkaline phosphatase11
Nausea1
Pain
 Headache, back, other3
 Breast3
 Limb3
Constipation1
Anorexia31
Fatigue51
Hemoglobin1
Vaginal dryness1
Diarrhea3
Hot flashes6
Limb edema6

NOTE: Grade 1 toxicities reported in >10% of patients (n = 28). No grade 4 or 5 events or treatment-related serious adverse events observed.