Table 2.

Dose-limiting toxicity of vismodegib in patients with medulloblastoma

Cohort/doseNo. patients enrolledNo. patients evaluable for DLTNo. patients with DLTDLT
Initial cohort
 85 mg/m2660
 170 mg/m2761Grade-3 γ-glutamyl transferase
Flat-dosing cohort
 150 mg1081Grade-4 hypokalemia
 300 mg1071Grade-3 thrombocytopenia