Table 4.

Summary of imetelstat pharmacokinetic parameters

Dose level
(mg/m2)No. of patientsCmax (μg/mL)Half-life (h)AUC (μg/mL•h)Cl (mL/h/m2)
225763.7 ± 18.73.7 ± 1.8307 ± 154855 ± 298
285696.7 ± 31.48.0 ± 5.3614 ± 248792 ± 602
3605164 ± 41.34.4 ± 1.51240 ± 395318 ± 117