Table 2.

Qualitative review of outcomes of the included studies

Predictive value of imaging response criteria
First author (reference number)K–M curve or HRPFS or OSRelapse rateResidual disease detectionAnalyzed parameters in meta-analysis
Bishu et al. (14)NoneNAPET− (7%, 1/14) vs. PET+ (100%, 2/2) CT− (11%, 1/9) vs. CT+ (29%, 2/7)aPET: SEN 94%, SPE 93%, PPV 94%, NPV 93% CT: NAPooled HR of PET and CT, CR rates, and discordance rates
Dupuis et al. (15)K–M curve for PET data
  • Two-year PFS rate

    PET− (87%) vs. PET+ (51%)

    CT− (83.2%) vs. CT+ (67.7%)

  • Two-year OS rate

    PET− (100%) vs. PET+ (88%)

    CT (NA)

NANAPooled HR of PET, CR rates and discordance rates
Janikova et al. (16)K–M curve for PET and CT dataNAPET− (26%, 19/73) vs. PET+ (70%, 14/20) CT− (29%, 21/72) vs. CT+ (57%, 12/21)aNAPooled HR of PET and CT, CR rates, and discordance rates
Le Dortz et al. (17)K–M curve for PET data
  • Median PFS

    PET− (48 mo) vs. PET+ (17.2 mo)

NAPET: SEN 100%, SPE 97%, PPV 92%, NPV 100%Pooled HR of PET, CR rates, and discordance rates
CT: SEN 100%, SPE 51%, PPV 43%, NPV 100%
Lopci et al. (18)K–M curve with uni- and multivariate HR for PET data
  • Three-year PFS rate

    PET− (40%) vs. PET+ (10%)

NANAPooled HR of PET
Lopci et al. (19)K–M curve with uni- and multivariate HR for PET dataNANAPET: SEN 100%, SPE 99%, PPV 89%, NPV 100%Pooled HR of PET
CT: NA
Trotman et al. (20)K–M curve with uni- and multivariate HR for PET and CT data
  • 42-month PFS rate

    PET− (70.7%) vs. PET+ (32.9%)

    CT− (66.9%) vs. CT+ (55.0% in PR, 0% in stable disease/PD)

  • 42-month OS rate

    PET− (96.5%) vs. PET+ (78.5%)

    CT (NA)

NANAPooled HR of PET and CT, CR rates and discordance rates
Zinzani et al. (21)None
  • Two-year PFS rate between PET−/CT+ and PET+/CT− (90% vs. 20%, P = 0.0031)

PET− (6%, 2/34) vs. PET+ (91%, 10/11) CT− (19%, 5/27) vs. CT+ (39%, 7/18)aNAPooled HR of PET and CT, CR rates, and discordance rates

Abbreviations: K-M, Kaplan–Meier; PFS, progression-free survival; OS, overall survival; SEN, sensitivity; SPE, specificity; PPV, positive predictive value; NPV, negative predictive value; NA, not available.

  • NOTE: aEstimated from data provided within the article.