Table 1.

Summarized report of the 36 patient samples and genetic alterations identified in the PI3K/AKT/PTEN pathway

Patient no.Gender (age)Cyst size (cm)Location within pancreasMain duct or mixed (MD) versus branch duct (BD)IPMN lesion analyzed histologic subtype gastric = G, intestinal = I, pancreatobiliary = P, and nuclear grade (1–3)Resection specimen (highest grade of IPMN)Resection specimen (stage of invasive cancer)OutcomePIK3CA mutantAKT1 mutantPIK3CA ampAKT ampPTEN LOH
1F (70)3.5HeadMainG (1)IPMN-2NEDNoNoNo
2F (79)2.2BodyMainP (3)IPMN-3pT1N0DODNoNoYes
3M (64)2.0HeadMainI (2)IPMN-3RecurrenceNoNoNo
4M (64)1.2HeadMainG (1)IPMN-3RecurrenceNoNoYes
5F (66)2.1HeadMainG (1)IPMN-1NEDNoNoNA
6M (78)4.5HeadBranchI (2)IPMN-3NEDYesNoNo
7M (85)5.5HeadN/AI (2)IPMN-3pT3N1DODE17KNoNoYes
8F (44)1.0HeadMainI (3)IPMN-3NEDNoNoYes
9F (70)3.0HeadMainP (3)IPMN-3NEDNoNoNo
10M (75)3.0HeadBranchP (3)IPMN-3Recur/DODNoNoNo
11F (79)2.0HeadMainG (3)IPMN-3NEDNoNoNo
12F (75)2.0TailBranchG (2)IPMN-2DODNoNoNo
13F (85)4.3BodyMainI (3)IPMN-3NEDNoNoNo
14F (36)4.8HeadMainG (2)IPMN-2NEDYesNoNo
15F (66)2.1HeadMainI (3)IPMN-3pT3N1Recur/DODYesNoNo
16F (68)1.7TailMainG (2)IPMN-2NEDH1047RNoNoNo
17F (59)5.0HeadBranchI (2)IPMN-3NEDNoNoYes
18M (70)5.2HeadBranchP (3)IPMN-3NEDNoNoNo
19M (73)5.5BodyMainG (2)IPMN-2NEDNoNoNo
20M (78)1.6HeadMainG (1)IPMN-3pT1N0NEDE17KNoNoNo
21F (58)1.0BodyMainG (1)IPMN-1NEDYesNoNo
22M (79)5.1TailMainP (3)IPMN-3pT3N1Recur/DODNoYesYes
23F (58)4.0BodyMainI (3)IPMN-3NEDNoNoNA
24M (71)5.0HeadMainI (3)IPMN-3NEDNoNoYes
25F (55)1.4Head/neckBranchG (3)IPMN-3NEDNoNoNA
26F (58)1.2BodyBranchG (2)IPMN-2NEDYesNoYes
27M (53)3.6TailMainP (3)IPMN-3NEDNoNoNo
28M (61)1.5HeadMainI (2)IPMN-3pT1N0NEDNoNoNo
29M (74)0.5Body/tailMainP (3)IPMN-3RecurrenceNoNoYes
30F (78)4.5DistalMainG (2)IPMN-2NEDNoNoNA
31F (67)2.6BodyMainG (2)IPMN-2NEDNoNoNA
32M (66)1.3DistalBranchI (3)IPMN-3NEDYesNoNo
33F (82)2.0HeadMainP (3)IPMN-3pT3N1DODNoNoNA
34M (68)2.0DistalMainI (3)IPMN-3NEDNoNoNA
35M (72)3.0DistalN/AI (3)IPMN-3NEDE17KYesNoNA
36F (78)1.1Head/bodyBranchI (2)IPMN-2NEDNoNoYes

IPMN-1 (low-grade dysplasia) = IPMN, adenoma; IPMN-2 (moderate dysplasia) = IPMN, borderline tumor; IPMN-3 (high-grade dysplasia) = IPMC, carcinoma in situ; NED, no evidence of diseases; DOD, death of disease; NA, not informative.