Table 1.

Clinicopathologic features and genomic alterations in 15 cases of micropapillary urothelial carcinoma of the urinary bladder

Study #GenderAge at time sample was obtainedSpecimen sequencedTumor typeTumor gradeTumor stageCoverage depthGenomic alterationsActionable alterationsAKT1ATK2ARID1AAURKABAP1CCND1CCND3CCNE1EGFREPHA3ERBB2 (allelic fraction)FBXW7HRASIDH2IRS2JAK2KRASMCL1MDM2MLL2MSH2MYCL1NF2PTCH1PIK3CAPIK3R1PTENRAF1RB1RICTORRUNX1TP53
1F71MetastasisMPUCHGIV1,52532S310F (25%)G423VR282W
2M63TURBTMPUCHGIV86374AmplificationAmplificationS310F (36%)S612*AmplificationQ298*E294fs*52
3M67MetastasisMPUCHGIV67543V661fs*15Homozygous LossS310Y (19%)Amplification
4F57CystectomyMPUCHGIV75383AmplificationAmplificationTruncation exon 48G617*fs36AmplificationR166QE258K, S215R
5F71MetastasisMPUCHGIV75753S1356fs*101AmplificationAmplificationM1417fs*15S183*
6M66TURBTMPUCHGII1,30563E17KE542KI290fs*4S397*AmplificationK132N
7M55TURBTMPUCHGI90411R157W (1%)
8F61CystectomyMPUCHGIII99931AmplificationY239*R175H
9M55CystectomyMPUCHGIII1,02252E1767*S310F (25%)E463KQ762*G244S
10M73CystectomyMPUCHGII1,10031AmplificationG12DSplice site 783-1G>A
11M86CystectomyMPUCHGIV87031AmplificationR140QAmplification
12M68TURBTMPUCHGI1,08264E17KY215*, Q1473*G12V, G12CV1081M
13M68TURBTMUPCHGII99963S361*AmplificationAmplificationAmplificationR273C, Q52fs*71
14F63MetastasisMUPCHGIV1,02221AmplificationG245S
15M67TURBTMUPCHGI79354AmplificationS310F (43%)AmplificationAmplificationQ344*