Table 1.

CI as a measurement of synergy for trabectedin and SN38 relative to trabectedin and doxorubicin for experimental data points and as determined by the median effect equation where the value of the CI indicates synergistic (<1), additive (= 1), and antagonistic (>1) drug interactions and the smaller the value the greater the synergy

Experimental pointsMedian effect equation
2× IC50IC500.5× IC50ED50ED75
Trabectedin and SN38TC320.84 (±0.02)0.57 (±0.02)1.05 (±0.12)0.51 (±0.06)0.66 (±0.05)
TC710.85 (±0.03)0.72 (±0.04)0.8 (±0.03)0.23 (±0.05)0.42 (±0.05)
Trabectedin and doxorubicinTC321.18 (±0.06)0.84 (±0.03)1.11 (±0.05)0.87 (±0.05)1.06 (±0.03)
TC710.95 (±0.01)0.85 (±0.03)1.12 (±0.11)0.65 (±0.12)0.86 (±0.11)

NOTE: Data represent the mean value (±SEM) from 3 independent experiments.