Table 2.

Treatment-related AEs by dose level and symptom

Rigosertib twice daily dosing (mg)70140280560700Total
Evaluable patients32333647
Patients with a DLT000112
Grade232323232323
Dysuria000000132a40172
Cystitis001000300040
Micturition urgency001000102040
Hematuria10000001a11b22
Urinary hesitancy000000100010
Abdominal discomfort000000001010
Abdominal distension000000001010
Abdominal pain000000001010
Nausea000000001010
Fatigue000000110011
Hypertonic bladder000000100010
Pelvic pain010000100011
Hyponatremia000000000101
  • aDLT (grade 3 hematuria and dysuria week 3).

  • bDLT (grade 3 hematuria week 2).