Table 1.

Demographic summary and disease characteristics at baseline

Baseline characteristicsAll patients (n = 103)
Age, median years (range)59.0 (22–87)
Male sex, %61.2
Primary site of cancer, n (%)
 Pancreas19 (18.4)
 Colorectal18 (17.5)
 Other gastrointestinal tumorsa8 (7.8)
 BCC16 (15.5)
 Lung10 (9.7)
 Medulloblastoma9 (8.7)
 Genitourinary tumorsb5 (4.9)
 Breast3 (2.9)
 Cutaneous melanoma3 (2.9)
 Otherc12 (11.7)
Prior antineoplastic therapies, n (%)
 Surgery91 (88.3)
 Radiotherapy47 (45.6)
 Systemic therapyd96 (93.2)
Prior systemic therapiesd
 120 (19.4)
 222 (21.4)
 >254 (52.4)
ECOG performance status, n (%)
 041 (39.8)
 155 (53.4)
 27 (6.8)
  • aOther gastrointestinal tumors included cholangiocarcinoma (4), stomach (1), gall bladder (1), esophageal (1), and small intestine (1).

  • bGenitourinary tumors included cervix (1), ovary (1), endometrial (1), prostate (1), and renal (1).

  • cOther included leiomyosarcoma (2), germ cell (2), mesothelioma (2), Merkel cell carcinoma (1), spindle cell carcinoma (1), osteosarcoma (1), adenocarcinoma of unknown primary (1), ciliary body melanoma (1), and ampulloma (1).

  • dIncluded chemotherapy, hormonal therapy, immunotherapy, and targeted therapy (1 patient with BCC was previously treated with the topical formulation of sonidegib).