Table 4.

Cancer-related exome variants seen exclusively in sensitive and resistant squamous cell carcinomas

GeneDescriptionChromosomeNucleotide changeAmino acid change
Nonsynonymous SNPs present in both sensitive tumors, but not in resistant tumors
 ABCC11ATP-binding cassette, subfamily C (CFTR/MRP), member 1116T>AN1277Y
 ACIN1Apoptotic chromatin condensation inducer 114T>CN20S
 FAT1FAT tumor suppressor homolog 1 (drosophila)4G>AA131V
 ROBO3Roundabout, axon guidance receptor, homolog 3 (drosophila)11G>AR416H
Nonsynonymous SNPs present in all resistant tumors, but not in sensitive tumors
 CDH23Cadherin-related 2310A>GN1351D
 HCLS1Hematopoietic cell-specific Lyn substrate 13C>TE361K