Table 2.

Multivariate Cox proportional hazard analysis for DFS and OS among patients with rectal cancer eligible for primary surgery

DFSOS
HR (95% CI)PHR (95% CI)P
Model before stepwise (stepAIC) selection
Age1.14 (0.74–1.75)0.56461.77 (1.3–2.42)0.0003
Tumor (T) stage1.63 (0.95–2.8)0.07501.23 (0.8–1.88)0.3535
N stage0.42 (0.08–2.28)0.31741.24 (0.43–3.54)0.6885
LNR4.03 (0.88–18.46)0.07271.69 (0.7–4.1)0.2426
VELIPI + (tumor emboli)0.79 (0.18–3.45)0.75640.57 (0.19–1.74)0.3244
Immunoscorea (I0 to I4)0.62 (0.44–0.87)0.00610.67 (0.5–0.89)0.0053
Model after stepwise (stepAIC) selection
Age1.66 (1.25–2.22)0.0005
Tumor (T) stage1.59 (0.94–2.7)0.0836
LNR1.88 (1.02–3.46)0.04141.89 (1.31–2.72).0007
Immunoscorea (I0 to I4)0.62 (0.44–0.88)0.00690.65 (0.49–0.85)0.0019
UICC TNM Staging1.43 (0.94–2.19)0.09771.41 (1.01–1.98)0.0437
Immunoscorea (I0 to I4)0.55 (0.39–0.79)0.00090.62 (0.47–0.81)0.0004

NOTE: All categorical covariates were transformed into numeric codes before they entered into the Cox model.

Abbreviation: AIC, Akaike information criterion.

  • aLeave-one-out method. Correction using C = 1 − (SE[coef]/coef)2; heuristic shrinkage factor corrected with Holländer et al. (20).