Table 5.

Regressions for the association of prostate cancer and serum 25-OH D levels in AAs

Biopsy status: prostate cancer (n = 168) vs. negative (n = 105) OR (95% CI)Stage: ≥ T2b (n = 47) vs. ≤ T2a (n = 118) OR (95% CI)Gleason: ≥ 3+4 (n = 73) vs. ≤ 3+3 (n = 92) OR (95% CI)Gleason: ≥ 4+4 (n = 25) vs. < 4+4 (n = 140) OR (95% CI)NCCN risk: ≥ intermediate (n = 65) vs. low (n = 100) OR (95% CI)
Serum 25-OH D < 20 ng/mL 2.43 (1.20–4.94)aSerum 25-OH D < 12 ng/mL 4.22 (1.52–11.74)bSerum 25-OH D < 12 ng/mL 3.61 (1.17–11.12)aSerum 25-OH D < 12 ng/mL 4.89 (1.59–15.07)bSerum 25-OH D < 12 ng/mL X ever drinka
Season (high UV/low UV) 1.22 (0.62–2.39)Season (high UV/low UV) 1.41 (0.50–3.96)Season (high UV/low UV) 1.72 (0.61–4.83)Season (high UV/low UV) 1.13 (0.37–3.45)Season (high UV/low UV) 1.36 (0.57–3.22)
Age 1.06 (1.01–1.11)aAge > 70 0.38 (0.08–1.92)Age > 70 2.26 (0.64–8.03)Age 1.06 (0.99–1.14)Age > 70 0.63 (0.19–2.09)
Serum PSA 1.04 (1.01–1.08)aSerum PSA 1.00 (0.99–1.00)Serum PSA 0.96 (0.91–1.01)Serum PSA 2.14 (1.28–3.58)b
Family history 4.04 (1.68–9.71)bHigh %positive cores 2.42 (0.91–6.44)Family history 1.45 (0.52–4.04)Family history 2.36 (0.71–7.83)
Current smoking 1.35 (0.61–2.98)Ever smoke 0.69 (0.25–1.90)Ever smoke 0.64 (0.18–2.19)
>2 drinks/day 0.49 (0.19–1.28)>2 drinks/day 0.19 (0.02–1.82)High % positive coresc 2.97 (1.08–8.17)aMarried (yes) 0.46 (0.13–1.59)High %positive coresc 2.90 (1.22–6.91)a
5-ARI use 0.08 (0.02–0.41)b5-ARI use 0.38 (0.03–5.17)5-ARI use 0.36 (0.02–5.56)5-ARI use 3.15 (0.42–23.41)5-ARI use 0.67 (0.06–7.95)

NOTE: Covariates in bold print have reached statistical significance with P < 0.05.

  • aP < 0.05.

  • bP < 0.01.

  • cHigh percent positive refers to having greater than or equal to 34% of the biopsy cores that were obtained containing prostate adenocarcinoma.