Table 1.

Statistically significant SNPs replicated in the PGSNPS dataset (phenotype: maximum TRSN)

GeneVariantSNP rs numberChromosomePosition DBSNP build 37Major/minor alleleType of SNP genotyped (G) imputed (I)Imputation R2ORa95% CIaP-valueIncluded in AML yes (Y) no (N)
CYP2C8*4rs10589301096818119G/CG1.481.02–2.150.04Y
ABCB1rs2032582787160618C/AI0.991.221.03–1.450.02Y
ABCB1**rs1045642787138645A/GG0.830.70–0.980.03N [high correlation with other SNP(s)]
ABCB1rs3213619787230193A/GI0.990.470.28–0.790.004Y
ABCC2rs818771010101611294G/AI10.630.42–0.930.02Y
ABCC2**rs1722272310101595996T/AI10.660.44–1.010.05N [high correlation with other SNP(s)]
CYP1B1*3rs1056836238298203G/CG0.810.68–0.960.02Y
TUBB2Ars950192963157854T/CI0.961.801.20–2.720.005Y
KIAA0146-PRKDbrs6473187848483958A/GI0.911.481.01–2.170.04Y
SLCO1B1crs38293061221292280C/TI0.990.660.44–1.010.05Y
EPHA6rs301927397346618A/GI0.991.351.07–1.700.01Y

Not all variants described in each study as having “no association with neuropathy” are reported in the table.

OR > 1 indicates an increased risk of TRSN.

OR < 1 indicates a decreased risk of TRSN.

  • aORs and 95% CIs represent the per-allele effect of the minor allele for any particular SNP.

  • brs6473187 in KIAA0146 is in complete LD with rs2632496 in KIAA0146, with rs4873774 in UBE2V2, and with rs8178108 in PRKD.

  • crs3829306 is in complete LD with rs4149013 and rs4149023, both in SLCO1B1.