Table 3.

Correlation of specific BRAFV600 mutations with select patient demographics and disease characteristics

WT BRAFMutant BRAFV600EV600K
Demographics and disease characteristicsn (%)n (%)P valuen (%)n (%)P value
Age at diagnosisa
 Young42 (43.8)43 (58.1)0.06334 (68)6 (40)0.051
 Old54 (56.3)31 (41.9)16 (32)9 (60)
ECOG PS
 066 (66.7)39 (48.8)0.01619 (34.6)13 (81.3)<0.001
 133 (33.3)41 (51.3)36 (65.5)3 (18.8)
Ulceration
 No39 (39.4)35 (43.8)0.83624 (43.6)6 (37.5)0.906
 Yes34 (34.3)25 (31.3)19 (34.6)6 (37.5)
 Unknown26 (26.3)20 (25)12 (21.8)4 (25)
LDH level
 Normal59 (61.5)42 (53.2)0.26929 (52.7)7 (46.7)0.677
 Elevated37 (38.5)37 (46.8)26 (47.3)8 (53.3)
Breslow depth
 Low35 (35.4)28 (35)0.48621 (38.2)3 (18.8)0.196
 High33 (33.3)21 (26.3)16 (29.1)4 (25)
 Missing31 (31.3)31 (38.8)18 (32.7)9 (56.3)
Clark levelb
 SubQ fat20 (31.8)8 (15.7)0.0834 (10.5)3 (37.5)0.095
 Reticular31 (49.2)35 (68.6)27 (71.1)5 (62.5)
 Other12 (19.1)8 (15.7)7 (18.4)0 (0)

NOTE: P values were from Fisher exact test for categorical and binary variables.

Abbreviation: SubQ fat, subcutaneous fat.

  • aMedian age cutoff = 58 years.

  • bFor Clark level, other includes interface papillary-reticular dermis, extension into papillary dermis, and above basal lamina.