Table 2.

Patient clinicopathologic characteristics and genetic biomarkers by LCS6 status

Carrier (N = 432)WT (N = 2,402)Total (N = 2,834)P
T stage, n (%)0.22a
  T1 or T275 (17.2)361 (82.8)436 (15.4)
  T3 or T4357 (14.9)2,040 (85.1)2,397 (84.6)
  Missing011
Number of positive LNs, n (%)0.24a
  1–3246 (14.6)1,440 (85.4)1,686 (59.5)
  ≥ 4186 (16.2)962 (83.8)1,148 (40.5)
Grade, n (%)0.94a
  High105 (15.2)588 (84.8)693 (24.5)
  Low327 (15.3)1,814 (84.7)2,141 (75.5)
PS, n (%)0.63a
 PS 0335 (15.4)1,834 (84.6)2,169 (76.6)
 PS 1 or 297 (14.7)564 (85.3)661 (23.4)
 Missing044
Site of disease, n (%)0.21a
  Right219 (15.5)1,197 (84.5)1,416 (50.2)
  Left208 (15.2)1,156 (84.8)1,364 (48.4)
  Both2 (5.1)37 (94.9)39 (1.4)
  Missing31215
Site of disease, n (%)0.81a
  Missing26149175
  Cecum93 (16.2%)482 (83.8%)575 (21.6%)
  Ascending colon57 (13.7%)359 (86.3%)416 (15.6%)
  Hepatic flexure15 (12.9%)101 (87.1%)116 (4.4%)
  Transverse colon36 (16.9%)177 (83.1%)213 (8.0%)
  Splenic flexure16 (15.1%)90 (84.9%)106 (4.0%)
  Descending colon26 (18.1%)118 (81.9%)144 (5.4%)
  Sigmoid colon163 (15.0%)926 (85.0%)1,089 (41.0%)
Bowel obstruction, n (%)0.77a
  Yes72 (15.7)387 (84.3)459 (16.2)
  No360 (15.2)2,015 (84.8)2,375 (83.8)
Bowel perforation, n (%)0.67a
  Yes20 (14.0)123 (86.0)143 (5.0)
  No412 (15.3)2,279 (84.7)2,691 (95.0)
BMI, n (%)0.14a
  Underweight (BMI < 20)10 (8.5)107 (91.5)117 (4.1)
  Normal weight (20≤ BMI<25)114 (15.6)617 (84.4)731 (25.9)
  Overweight (25≤ BMI<30)147 (14.6)863 (85.4)1,010 (35.8)
  Obese (BMI ≥ 30)158 (16.4)806 (83.6)964 (34.2)
  Missing3912
KRAS, n (%)0.88a
  Missing138497
  Mutant150 (15.2)839 (84.8)989 (36.1)
  WT269 (15.4)1,479 (84.6)1,748 (63.9)
BRAF, n (%)0.33a
  Missing20139159
  Mutant58 (17.2)279 (82.8)337 (12.6)
  WT354 (15.1)1,984 (84.9)2,338 (87.4)
MMR, n (%)0.68a
  Missing128193
  pMMR375 (15.4)2,056 (84.6)2,431 (88.7)
  dMMR45 (14.5)265 (85.5)310 (11.3)

Abbreviations: LNs, lymph nodes; PS, performance score; BMI, body mass index; MMR, mismatch repair.