Table 3.

Association between the LCS6-variant and DFS stratified by KRAS, BRAF, and MMR status

HR (95% CI)P
KRAS mutation status
 LCS6 TT, KRAS WT (n = 1,479)0.73 (0.62–0.86)0.002
 LCS6 TT, KRAS mutant (n = 839)Ref. (Ref.)Ref.
 LCS6 GT/GG, KRAS WT (n = 269)0.73 (0.55–0.96)0.025
 LCS6 GT/GG, KRAS mutant (n = 150)0.83 (0.59–1.18)0.304
BRAF mutation status
 LCS6 TT, BRAF WT (n = 1,984)1.18 (0.93–1.51)0.17
 LCS6 TT, BRAF mutant (n = 279)1.47 (1.08–2.00)0.015
 LCS6 GT/GG, BRAF WT (n = 354)Ref. (Ref.)Ref.
 LCS6 GT/GG, BRAF mutant (n = 58)1.81 (1.13–2.91)0.015
MMR status
 LCS6 TT, pMMR (n = 2,056)1.09 (0.61–1.92)0.78
 LCS6 TT, dMMR (n = 265)1.13 (0.61–2.08)0.70
 LCS6 GT/GG, pMMR (n = 375)1.03 (0.56–1.88)0.93
 LCS6 GT/GG, dMMR (n = 45)Ref. (Ref.)Ref.