Table 1.

Patient demographics by KRAS-LCS6 status

Carrier (N = 432)WT (N = 2,402)Total (N = 2,834)P
Age, y0.39a
  N432 (15.2)2,402 (84.8)2,834 (100.0)
  Median58.0058.0058.00
  Range(22.00–85.00)(19.00–86.00)(19.00–86.00)
Age, n (%)0.18b
  <5089 (13.6)566 (86.4)655 (23.1)
  ≥ 50343 (15.7)1,836 (84.3)2,179 (76.9)
Sex, n (%)0.91b
  Female201 (15.2)1,125 (84.8)1,326 (46.8)
  Male231 (15.3)1,277 (84.7)1,508 (53.2)
Race, n (%)<0.0001b
  Caucasian419 (17.2)2,021 (82.8)2,440 (87.5)
  Black or African-American6 (3.1)190 (96.9)196 (7.0)
  Asian1 (0.8)131 (99.2)132 (4.7)
  Other0 (0.0)22 (100.0)22 (0.8)
Missing63844
Treatment arms, n (%)0.78b
 FOLFOX177 (15.1)997 (84.9)1,174 (41.4)
 FOLFIRI15 (17.2)72 (82.8)87 (3.1)
 FOLFOX × 6 → FOLFIRI × 612 (12.4)85 (87.6)97 (3.4)
 FOLFOX + C225168 (14.9)956 (85.1)1,124 (39.7)
 FOLFIRI+ C2253 (10.0)27 (90.0)30 (1.1)
 FOLFOX × 6 → FOLFIRI × 6 + C2256 (19.4)25 (80.6)31 (1.1)
 Treatment per local physician discretion51 (17.5)240 (82.5)291 (10.3)
  • aUnequal variance two-sample t test.

  • bχ2 test.