Table 1.

Univariate Cox proportional HRs and P values for immune gene signature expression versus metastasis-free survival (breast, n = 855) or PFS (ovarian, n = 266)

IGG_ClusteraTNBC_B-CellbB_CellaB_Cell_60 genecB_Cell_clusterdT_CellaTNBC_T-cellbLCKaCD8aT_Cell_clusterdCD8_clusterd
nHRPHRPHRPHRPHRPHRPHRPHRPHRPHRPHRP
Breast
 All breast8550.8476.61E−040.9011.56E−030.5851.52E−020.8884.79E−040.7829.38E−040.5625.31E−030.9013.83E−020.8883.37E−02NS0.8582.27E−020.8651.81E−02
 Luminal A243NSNSNSNSNSNSNSNSNSNSNS
 Luminal B162NSNSNSNSNS0.3041.59E−02NSNSNSNSNS
 HER2-enriched1440.7554.67E−030.8271.12E−020.3239.16E−030.7912.43E−030.6414.34E−030.3286.01E−030.7454.74E−030.7256.39E−030.6583.29E−020.6875.03E−030.7054.15E−03
 Basal-like1400.5991.20E−040.6864.24E−050.172.39E−030.6826.05E−050.4913.56E−040.1262.44E−040.6441.00E−030.6191.34E−030.4721.53E−030.4961.29E−040.5482.35E−04
 Claudin-low90NSNSNSNSNSNSNSNSNSNSNS
Ovarian
 All ovarian2660.8457.40E−03NSNS0.8574.09E−030.8565.63E−03NSNSNSNSNSNS
 Immunoreactive770.6757.43E−03NSNS0.7291.68E−020.7251.22E−020.1772.25E−02NSNSNS0.6862.99E−020.7074.28E−02
 Mesenchymal420.6733.32E−02NSNS0.7144.31E−02NSNSNSNSNSNSNS
 Differentiated65NSNSNSNSNSNSNSNSNSNSNS
 Proliferative78NSNSNSNSNSNSNSNSNSNSNS

NOTE: NS indicates nonsignificant P values (P ≥ 0.05). Superscript indicates origin of gene signature.

  • aFan et al. (11).

  • bRody et al. (15).

  • cSchmidt et al. (12).

  • dHierarchical clustering of breast cancer mRNA-seq data (n = 728).