Table 4.

Summary of mean pharmacokinetic parameters by dose cohort

TmaxCmaxAUC0-last
CohortNVTX-2337 dose (mg/m2)HoursnHoursnng/mLnng•hr/mLn
130.10.5331.7311.5232.993
240.20.7543.0741.9744.104
330.40.5136.9726.6930.473
460.80.5265.5465.94617.706
531.30.4937.14210.91327.493
632.00.5137.04314.64355.483
732.80.5135.71319.87377.453
883.90.5085.55723.03877.838
Total330.54335.452811.773338.3033