Table 2.

Summary of TP53 mutations identified in our study, classified according to their functional effects

Training cohortValidation cohort
Type of mutationEGFR wt (n = 43)EGFR mutated (n = 50)EGFR mutated (n = 17)
Disruptive15 (35%)24 (48%)6 (35%)
 Frameshift deletions05 (10%)2 (12%)
 In-frame deletions within L2-L303 (6%)0
 Nonsense8 (19%)1 (2%)3 (17%)
 Missense within L2-L3a7 (16%)13 (26%)1 (6%)
 Intronic02 (4%)0
Nondisruptive28 (65%)26 (52%)11 (65%)
 In-frame deletions outside L2-L301 (2%)0
 Missenseb28 (65%)25 (50%)11 (65%)
  • aReplacing a residue with another of a different polarity or charge.

  • bOutside the L2-L3 loops or, if within L2-L3, replacing a residue with another of the same polarity or charge.