Table 3.

Results of the univariate and multivariate analyses of selected factors for OS in the training cohort

Univariate analysisMultivariate analysis
VariableNHR for death (95% CI)P valueHR for death (95% CI)P value
EGFR status
 Mutated19311
 wt1251.96 (1.46–2.62)<0.0011.22 (0.77–1.93)0.41
Age3150.99 (0.98–1.01)0.691.01 (0.98–1.02)0.84
Gender
 Female17811
 Male1401.77 (1.32–2.36)<0.0011.29 (0.85–1.94)0.24
Smoking status
 Never smokers1711
 Current + former smokers1021.78 (1.33–2.40)<0.0011.18 (0.74–1.88)0.48
Histology
 Nonsquamous28311
 Squamous352.49 (1.67–3.72)<0.0012.32 (1.32–4.08)0.003
Stage
 IIIB2511
 IV2931.70 (0.95–3.05)0.082.08 (0.75–5.78)0.16
ECOG PS
 07511
 ≥12341.83 (1.26–2.65)0.0012.03 (1.24–3.34)0.005
Brain metastases
 No27211
 Yes371.46 (0.95–2.24)0.091.56 (0.94–2.58)0.09
Bone metastases
 No22111
 Yes881.80 (1.32–2.46)<0.0012.25 (1.53–3.29)<0.001
TP53
 wt+ D26411
 NoD542.08 (1.46–2.97)<0.0011.89 (1.09–3.26)0.02
KRAS status
 wt+ others25411
 G12C162.19 (1.42–3.36)<0.0012.10 (1.19–3.71)0.01

Abbreviations: D, disruptive; ECOG PS, Eastern Cooperative Oncology Group Performance Status; NoD, nondisruptive.