Table 1.

Prevalence of MMR and BRAFMT status in patients with mCRC subdivided by study

dMMRpMMRTotalBRAFMTBRAFWTTotal
CAIRO18 (5.6%)304 (94.4%)32225 (7.8%)297 (92.2%)322
CAIRO229 (5.6%)487 (94.4%)51645 (8.7%)471 (91.3%)516
COIN65 (4.4%)1,396 (95.6%)1,461120 (8.2%)1,341 (91.8%)1,461
FOCUS41 (5.4%)723 (94.6%)76460 (7.9%)704 (92.1%)764
Pooled dataset153 (5.0%)2,910 (95.0%)3,063250 (8.2%)2,813 (91.8%)3,063
P0.6140.943

NOTE: P values represent heterogeneity between the four studies.

Abbreviations: mt, mutant tumors; wt, wild-type tumors.