Table 3.

Cox proportional hazard regression models for CaPSURE cohort (time from RP to PSA recurrence) and JHU cohort (time from PSA recurrence to clinical metastasis)

Time period (source)CovariateHR (95% CI)P
Treatment to PSA recurrence (CaPSURE)Age, y1.01 (0.99–1.02)0.299
log(PSA) [log(ng/mL)]2.45 (2.15–2.78)<0.001
GS
 ≤6Ref.
 71.59 (1.28–1.96)<0.001
 ≥83.23 (2.37–4.41)<0.001
Stage
 ≤T2aRef.
 >T2a1.35 (1.10–1.64)0.004
PSA recurrence to metastasisTime to PSA recurrence, y0.99 (0.79–1.25)0.963
GS ≤ 6 (JHU)Treatment
 No salvageRef.
 Salvage0.44 (0.12–1.71)0.239
PSA recurrence to metastasisTime to PSA recurrence, y0.86 (0.78–0.95)0.003
GS = 7 (JHU)Treatment
 No salvageRef.
 Salvage0.30 (0.20–0.44)<0.001
PSA recurrence to metastasisTime to PSA recurrence, y0.79 (0.64–0.97)0.027
GS ≥ 8 (JHU)Treatment
 No salvageRef.
 Salvage0.18 (0.10–0.32)<0.001