Table 1.

Demographics, tumor characteristics, and clinical outcomes in stage IIIB and IIIC patients

MeasureAll patients (N = 136)Stage IIIB (N = 38)Stage IIIC (N = 98)P
Gender, n (%)
 Male94 (69)25 (66)69 (70)0.680a
 Female42 (31)13 (34)29 (30)
Age at Stage III diagnosis (y), median (range)55.4 (24.9–85.4)54.3 (26.1–85.4)55.7 (24.9–84.0)0.684b
Mutation, n (%)
 BRAF55 (40)15 (39)40 (41)1.000a
 NRAS13 (10)4 (11)9 (9)
 WT68 (50)19 (50)49 (50)
PTEN, n (%)
 Absent31 (25)8 (24)23 (25)1.000a
 Not absent93 (75)25 (76)68 (75)
 Missing1257
Time to any distant recurrence (y), median (95% CI)1.1 (0.8–1.4)1.6 (1.0–3.3)0.8 (0.6–1.3)0.057c
OS (y), median (95% CI)2.2 (1.9–3.2)5.0 (2.3–6.5)1.9 (1.5–2.4)0.005c

Abbreviation: CI, confidence interval.

  • aFisher exact test.

  • bWilcoxon rank-sum test.

  • cLog-rank test.