Ponatinib IC50 values (nmol/L) in cell lines established from tumor biopsies in patients with GIST
| Cell line | KIT status | Ponatinib | Imatinib | Sunitinib | Regorafenib |
|---|---|---|---|---|---|
| GIST882 | K642E | 31 | 173 | 54 | 503 |
| GIST430 | Δ560–576 | 12 | 61 | 68 | 191 |
| GIST430/654 | Δ560–576/V654A | 159 | 1,204 | 90 | 1,001 |
| GIST430/654/680 | Δ560–576/V654A/N680K | 330 | >5,000 | 1,314 | 4,969 |
| GIST-T1 | Δ560–578 | 5 | 30 | 15 | 110 |
| GIST-T1/670 | Δ560–578/T670I | 8 | >5,000 | 48 | 249 |
| GIST-T1/816 | Δ560–578/D816E | 23 | 604 | 3,111 | 395 |
| GIST-T1/829 | Δ560–578/A829P | 16 | 1,201 | 1,168 | 934 |
| GIST48/820 | V560D/D820A | 34 | 413 | 587 | 164 |
| GIST48B | KIT-independent | 806 | >5,000 | >5,000 | >5,000 |
| GIST226 | KIT-independent | 2,807 | >5,000 | 3,856 | >5,000 |