Table 1.

Ponatinib IC50 values (nmol/L) in cell lines established from tumor biopsies in patients with GIST

Cell lineKIT statusPonatinibImatinibSunitinibRegorafenib
GIST882K642E3117354503
GIST430Δ560–576126168191
GIST430/654Δ560–576/V654A1591,204901,001
GIST430/654/680Δ560–576/V654A/N680K330>5,0001,3144,969
GIST-T1Δ560–57853015110
GIST-T1/670Δ560–578/T670I8>5,00048249
GIST-T1/816Δ560–578/D816E236043,111395
GIST-T1/829Δ560–578/A829P161,2011,168934
GIST48/820V560D/D820A34413587164
GIST48BKIT-independent806>5,000>5,000>5,000
GIST226KIT-independent2,807>5,0003,856>5,000