Table 1.

Identification of a panel of BTICs representative of the combinations of EGFR and PTEN mutations that exist in GBM

Sample no.DiagnosisAgeSexEGFR statusPTEN statusMGMT status
41GBM-r49MWTWTU
75GBM74MWTWTU
134GBM50FWTWTU
206GBM68MWTWTM
12GBM-r59MWTFrameshift Del codon 328U
30GBM67MWTN49IU
50GBM61MWTD326HM
84GBM67MWTV341FM
63GBM59FvIIIWTM
68GBM59MvIIIWTU
73GBM52MvIIIIns intron 5M
103GBM52MvIIIFrameshift Del codon 378U
147GBM56MvIIIFrameshift Ins codon 174U

NOTE: GBM-r, samples obtained from tumors at recurrence following initiation of radiation and temozolomide; M and U, samples with methylated and unmethylated MGMT promoters, respectively.