Table 2.

Univariate Cox regression analyses of the SII with clinicopathologic characteristics (training cohort, n = 133 and validation cohort, n = 123)

OSTTR
VariablesHR (95% CI)PHR (95% CI)P
Training cohort
 Age, y (>50 vs. ≤50)0.93 (0.58–1.49)0.7670.79 (0.49–1.26)0.324
 Sex (male vs. female)1.06 (0.57–1.98)0.8500.84 (0.43–1.63)0.597
 Liver cirrhosis (yes vs. no)0.79 (0.44–1.41)0.4220.80 (0.44–1.43)0.443
 Child–Pugh (B vs. A)2.10 (0.29–15.23)0.4620.05 (0.00–15717.06)0.641
 HBsAg (positive vs. negative)1.01 (0.58–1.74)0.9831.12 (0.64–1.96)0.681
 ALT, U/L (>40 vs. ≤40)1.42 (0.89–2.27)0.1411.44 (0.90–2.31)0.131
 AFP, ng/mL (>20 vs. ≤20)2.16 (1.31–3.55)0.0031.67 (1.03–2.71)0.037
 Tumor encapsulation (none vs. complete)1.73 (1.08–2.76)0.0220.66 (0.41–1.05)0.081
 Tumor differentiation (III–IV vs. I–II)1.60 (0.97–2.64)0.0661.66 (1.01–2.74)0.048
 Tumor size, cm (>5 vs. ≤5)2.77 (1.71–4.47)<0.0012.29 (1.40–3.74)0.001
 Tumor number (multiple vs. single)1.10 (0.72–1.68)0.6600.97 (0.60–1.58)0.900
 Vascular invasion (yes vs. no)2.17 (1.36–3.48)0.0012.44 (1.52–3.92)<0.001
 BCLC (B+C vs. 0+A)2.15 (1.35–3.43)0.0011.90 (1.19–3.05)0.008
 NLR (≥5 vs. <5)2.65 (1.49–4.72)0.0012.58 (1.44–4.61)0.001
 PLR (≥150 vs. <150)1.83 (1.09–3.06)0.0221.76 (1.06–2.91)0.028
 SII (≥330 vs. <330)2.62 (1.63–4.20)<0.0012.78 (1.72–4.48)<0.001
Validation cohort
 Age, y (>50 vs. ≤50)1.17 (0.54–2.57)0.6900.94 (0.56–1.58)0.828
 Sex (male vs. female)2.38 (0.71–7.96)0.1591.79 (0.71–4.48)0.214
 Liver cirrhosis (yes vs. no)0.77 (0.32–1.85)0.5630.83 (0.47–1.48)0.531
 Child–Pugh (B vs. A)6.66 (0.89–50.07)0.0650.05 (0.00–3147.99)0.593
 HBsAg (positive vs. negative)1.25 (0.30–5.32)0.7591.90 (0.69–5.24)0.217
 ALT, U/L (>40 vs. ≤40)1.55 (0.71–3.40)0.2731.58 (0.95–2.65)0.081
 AFP, ng/mL (>20 vs. ≤20)3.44 (1.03–11.51)0.0452.49 (1.29–4.82)0.006
 Tumor encapsulation (none vs. complete)0.36 (0.16–0.81)0.0130.51 (0.30–0.85)0.011
 Tumor differentiation (III–IV vs. I–II)1.71 (0.78–3.76)0.1851.51 (0.89–2.57)0.130
 Tumor size, cm (>5 vs. ≤5)1.84 (0.84–4.02)0.1302.30 (1.37–3.85)0.002
 Tumor number (multiple vs. single)0.86 (0.20–3.66)0.8431.17 (0.50–2.72)0.718
 Vascular invasion (yes vs. no)2.15 (0.98–4.71)0.0562.18 (1.30–3.65)0.003
 BCLC (B+C vs. 0+A)2.00 (0.84–4.79)0.1202.32 (1.30–4.15)0.004
 NLR (≥5 vs. <5)1.70 (0.51–5.68)0.3892.72 (1.28–5.77)0.009
 PLR (≥150 vs. <150)2.22 (0.66–7.42)0.1961.77 (0.71–4.44)0.222
 SII (≥330 vs. <330)3.12 (1.42–6.88)0.0033.19 (1.90–5.37)<0.001

Abbreviation: HBsAg, hepatitis B surface antigen.