Table 3.

Treatment emergent adverse events with a frequency of >15%

Any gradeGrade 3 or 4
Adverse eventsNumber of patients (%)
Combination phase
 Nausea63 (70.8)4 (4.5)
 Fatigue54 (60.7)9 (10.1)
 Anorexia38 (42.7)5 (5.6)
 Vomiting28 (31.5)2 (2.2)
 Constipation27 (30.3)1 (1.1)
 Anemia26 (29.2)10 (11.2)
 Neutropenia26 (29.2)15 (16.9)
 Diarrhea25 (28.1)1 (1.1)
 Weight decrease18 (20.2)2 (2.2)
 Dysgeusia17 (19.1)0
 Asthenia15 (16.9)1 (1.1)
 Peripheral edema15 (16.9)0
 Dizziness15 (16.9)0
 Non–cardiac chest pain15 (16.9)3 (3.4)
 Dyspnea14 (15.7)3 (3.4)
 Rash14 (15.7)0
Single-agent phase
 Dyspnea13 (23.2)3 (5.4)
 Nausea11 (19.6)0
 Peripheral neuropathy10 (17.9)0
 Fatigue10 (17.9)3 (5.4)
 Non–cardiac chest pain9 (16.1)0