Table 3.

Overview of treatment-emergent AEs

n (%)Total (N = 70)
Any AE70 (100)
Worst CTCAE grade of AE
 Grade 10
 Grade 23 (4.3)
 Grade 342 (60.0)
 Grade 414 (20.0)
Any serious AE44 (62.9)
Deatha11 (15.7)
AE leading to dose modificationb67 (95.7)
AE leading to permanent discontinuation of study drugc19 (27.1)

Abbreviation: CTCAE, Common Terminology Criteria for Adverse Events.

  • aIncluding during treatment or within 30 days after last dose of study treatment was taken.

  • bModifications include delays, interruptions, and reductions.

  • cIncluding discontinuation due to death.