Table 4.

Summary of correlative studies

Evaluable patients (N = 23)
Relative change in variable between baseline and repeat biopsy after 3 weeks on GDC-0449Patients, n%
Ki-67 index, IHC
 Evaluable patients, n1768
 >20% decrease317.65
 ≤20% decrease635.29
 Increase847.06
 Median−1.07
CSCs,% FACS
 Evaluable patients, n2184
 >20% decrease1047.62
 ≤20% decrease14.76
 Increase1047.62
 Median−16.08
Fibrosis, trichrome
 Evaluable patients, n2288
 >50% decrease313.64
 0–50% decrease731.82
 Increase1254.54
 Median0
GLI1, qRT-PCR
 Evaluable patients, n23100
 >50% decrease1982.61
 0–50% decrease313.04
 Increase14.35
 Median−93
PTCH1, qRT-PCR
 Evaluable patients, n23100
 >50% decrease939.13
 ≤50% decrease1043.48
 Increase417.39
 Median−38