Table 3.

Univariate and multivariate Cox regression analyses of DFS for stage I and II (n = 78) validation cases comparing the prognostic GEP with AJCC stage and individual staging factors

UnivariateMultivariate
Factor (high-risk variable)HR (95% CI)PHR (95% CI)P
GEP (class 2)20.3 (5.8–70.8)2.88E−069.55 (2.3–39.5)0.002
AJCC (IIB/IIC)15.2 (5.8–39.7)5.97E−075.40 (1.8–15.7)0.002
Breslow thickness (>0.75)165.6 (10.7–25.59)0.0003
Ulceration (present)13.1 (4.8–35.6)8.10E−07
Mitotic rate (>1/mm2)1.69 (0.5–5.8)0.407
Age (>50 y)5.6 (1.3–23.9)0.021