Table 1.

Discriminant genes included in the prognostic genetic signature for cutaneous melanoma metastatic risk

Gene symbolGene titleDirection of regulation in class 2Pa
BAP1bBRCA1-associated protein-1Down0.007
MGPMatrix Gla proteinDown0.486
SPP1Secreted phosphoprotein 1Up6.08 e-16
CXCL14Chemokine (C-X-C motif) ligand 14Down3.31 e-12
CLCA2Chloride channel accessory 2Down1.02 e-08
S100A8S100 calcium-binding protein A8Down0.031
BTG1B-cell translocation gene 1, antiproliferativeDown0.024
SAP130Sin3A-associated protein, 130 kDaDown0.024
ARG1Arginase 1Down1.05E-08
KRT6BKeratin 6BUp0.160
GJA1Gap junction protein, alpha 1, 43 kDaDown0.034
ID2Inhibitor of DNA binding 2, dominant negative helix-loop-helix proteinDown3.91 e-06
EIF1BEukaryotic translation initiation factor 1BUp0.024
S100A9S100 calcium-binding protein A9Down0.012
CRABP2Cellular retinoic acid binding protein 2Down0.0006
KRT14Keratin 14Down1.75 e-05
ROBO1Roundabout, axon guidance receptor, homolog 1 (Drosophila)Down0.0004
RBM23RNA-binding motif protein 23Down0.018
TACSTD2Tumor-associated calcium signal transducer 2Down0.037
DSC1Desmocollin 1Down7.00 e-09
SPRR1BSmall proline-rich protein 1BDown0.001
TRIM29Tripartite motif containing 29Down2.34 e-09
AQP3Aquaporin 3 (Gill blood group)Down5.08 e-06
TYRP1Tyrosinase-related protein 1Down2.41 e-06
PPLPeriplakinDown5.59 e-11
LTA4HLeukotriene A4 hydrolaseDown0.0001
CST6Cystatin E/MDown1.02 e-08
  • aP value reflects t-test analysis of ΔCt values from nonmetastatic cases compared with metastatic cases within the 268 sample cohort.

  • bTwo assays for BAP1 were included to target both the 5′ and 3′ regions of the gene.