Table 4.

The expression difference of sputum miRNAs between patients with either malignant or benign SPNs, the AUC values and corresponding sensitivity and specificity in distinguishing malignant from benign SPNs

miRNAsMean (SEM) of miRNA levela in patients with malignant SPNsMean (SEM) of miRNA levela in patients with benign SPNsPAUC (95% CI)SensitivitySpecificity
miR20585.66 (19.16)72.72 (64.82)0.02670.635 (0.552–0.719)59.7453.93
miR7081.01 (0.17)4.86 (1.37)0.00480.656 (0.561–0.750)64.7162.50
miR375698.81 (185.83)81.26 (23.80)0.00260.666 (0.594–0.756)66.2362.22
miR200b879.82 (228.67)49.10 (3.11)0.00130.679 (0.589–0.768)65.2261.19
miR18243.95 (12.76)2.16 (0.31)0.00180.684 (0.611–0.778)64.9459.76
miR15523.76 (4.59)4.54 (0.59)<0.00010.697 (0.616–0.779)62.6762.96
miR372136.49 (32.55)17.58 (3.56)0.00060.707 (0.628–0.786)63.6460.98
miR1439.46 (1.87)1.86 (0.27)0.00020.723 (0.644–0.803)63.3861.73
miR486-5p29.46 (4.18)241.62 (49.80)0.00010.748 (0.674–0.821)74.0366.67
miR1263.83 (1.38)78.88 (23.62)0.00300.777 (0.704–0.851)77.6375.00
miR312.73 (0.45)0.47 (0.07)<0.00010.789 (0.719–0.849)60.2382.67
miR2153.60 (6.43)7.56 (1.39)<0.00010.819 (0.753–0.874)78.1671.08
miR21067.28 (6.07)5.79 (0.42)<0.00010.853 (0.792–0.901)75.2785.88
Combined three miRNAsb<0.00010.919 (0.864–0.956)82.9387.84

Abbreviation: CI, confidence interval.

  • aThe relative expression of each miRNA was calculated by using 2−ΔΔ threshold cycle (Ct) in which, ΔCt were CT values normalized to miR16 control gene.

  • bThe three miRNAs: miR21, 31, and 210.