Table 2.

Univariate and multivariate analyses of factors affecting DFS in stage I–III patients (patient data from cohorts 1, 2, and 3 were pooled together; N = 903)

Univariate analysisaMultivariate analysisb
VariablesPatients (n)5-Year DFSPHR (95% CI)P
Agec
 <70 y47570.1%
 ≥70 y42775.3%0.221
Gender
 Male49269.3%1.00 (—)
 Female41176.0%0.0860.80 (0.61–1.05)0.105
Location0.0140.070
 Right colon36573.3%1.00 (—)
 Left colon46769.4%1.18 (0.90–1.56)0.228
 Rectum3077.5%1.23 (0.56–2.67)0.606
 Unknown4197.3%0.11 (0.02–0.76)0.026
Adjuvant chemotherapy<0.0010.859
 Undone45878.0%1.00 (—)
 Done31366.6%0.94 (0.68–1.30)0.716
 Unknown13267.9%0.90 (0.60–1.34)0.593
Stage<0.001<0.001
 I8595.7%1.00 (—)
 II44679.7%4.80 (1.50–15.29)0.008
 III37259.0%11.88 (3.69–38.26)<0.001
YAP1 status
 IYCC63177.5%1.00 (—)
 AYCC27261.2%<0.0011.63 (1.25–2.13)<0.001
  • aIn univariate analyses, log-rank tests were conducted.

  • bIn the multivariate Cox proportional hazard model, only variables with P < 0.15 in univariate analysis were included and the “enter method” was applied.

  • cData on age of one patient were missing.