Table 3.

Association between aspirin and/or NSAID use and prostate cancer risk or disease grade versus nonuse

Aspirin and/or NSAID users
VariableNonusersOR (95% CI)P value
Overall prostate cancer risk
 Number with cancer/total753/3,169683/3,221
 UnivariableReferent0.86 (0.77–0.97)0.014
 MultivariableaReferent0.87 (0.76–0.99)0.030
Low-grade disease
 Number with cancer/totalb520/2,953480/3,018
 UnivariableReferent0.88 (0.77–1.01)0.06
 MultivariableaReferent0.90 (0.77–1.04)0.15
High-grade disease
 Number with cancer/totalc233/2,665203/2,741
 UnivariableReferent0.83 (0.68–1.01)0.06
 MultivariableaReferent0.80 (0.64–0.99)0.040
  • aAdjusted for age, race, geographic region, PSA levels, prostate volume, digital rectal examination findings, BMI, treatment arm, smoking, alcohol, statin use, hypertension, diabetes, and cardiovascular disease.

  • bNumbers reflect men included in the analysis: those with low-grade disease and those without cancer.

  • cNumbers reflect men included in the analysis: those with high-grade disease and those without cancer.