Table 2.

Dose-limiting toxicities in cycle 1

Dose levelDose (mg/m2)Evaluated patients, nPrior chemotherapy regimens (median)DLT, nDLT
01.534.30
1332.30
2564.31Infection Gr 5
3731.30
49123.41PLT Gr 4
512342ANC Gr 4 PLT prolonged Gr2/3